1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy-

1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy- - Names and Identifiers

Name	1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy-
Synonyms	7-Hydroxy-2,3-dihydroisoindol-1-one 7-Hydroxy-2,3-dihydro-1H-isoindol-1-one 2,3-dihydro-7-hydroxy-1H-Isoindol-1-one 1H-Isoindol-1-one,2,3-dihydro-7-hydroxy- 1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy-
CAS	1033809-85-6

1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy- - Physico-chemical Properties

Molecular Formula	C8H7NO2
Molar Mass	149.15
Boling Point
Storage Condition	2-8°C

1H-Isoindol-1-one, 2,3-dihydro-7-hydroxy- - Introduction

2,3-Dihydro-7-hydroxy-1H-isoindol-1-one (abbreviated DHON) is an organic compound. The following is a description of the nature, use, preparation and safety information of DHON:

Nature:
-Appearance: White crystal powder
-Chemical formula: C9H7NO2
-Molecular weight: 161.16g/mol
-Melting point: about 140-142°C
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dimethylformamide

Use:
DHON has a variety of applications, including:
-Drug research: As a drug intermediate, participate in the synthesis of various drug compounds, especially some anti-tumor and anti-biological active compounds
-Pesticide R & D: Used as a key intermediate in pesticide synthesis
-Chemical research: catalysts for organic synthesis reactions and chemical synthesis

Preparation Method:
A commonly used method is to obtain DHON through a two-step synthesis:
1.2-(1-hydroxyindol-3-yl) acetic acid was prepared according to an existing method.
2.2-(1-hydroxyindol-3-yl) acetic acid is reacted with sulfuryl chloride to give 2,3-dihydro-7-hydroxy-1H-isoindol-1-one.

Safety Information:
The specific safety of DHON needs to be evaluated according to experimental conditions and specific use cases. In general, the handling and use of chemicals should be guided by the following principles:
-Avoid contact with skin and eyes, if contact, immediately rinse with plenty of water.
-Avoid inhaling its dust or vapor, and operate in a well-ventilated place.
-Before use should read and follow the appropriate safety guidelines and personal protective measures.
-Avoid contact with strong oxidants during storage, and keep away from fire and heat sources.

Please note that this introduction is for reference only. For the safety of DHON and the preparation method, please refer to the relevant chemical literature and safety operation guidelines.

Last Update：2024-04-09 15:17:50